Redox-Based Flagging of the Global Network of Oxidative Stress Greatly Promotes Longevity.
Identifieur interne : 000342 ( Main/Exploration ); précédent : 000341; suivant : 000343Redox-Based Flagging of the Global Network of Oxidative Stress Greatly Promotes Longevity.
Auteurs : Donatella Canistro [Italie] ; Caterina Boccia [Italie] ; Rosanna Falconi [Italie] ; Barbara Bonamassa [États-Unis] ; Luca Valgimigli ; Fabio Vivarelli ; Antonio Soleti ; Maria Luisa Genova [Italie] ; Giorgio Lenaz [Italie] ; Andrea Sapone ; Francesco Zaccanti [Italie] ; Sherif Z. Abdel-Rahman [États-Unis] ; Moreno PaoliniSource :
- The journals of gerontology. Series A, Biological sciences and medical sciences [ 1758-535X ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Composés organométalliques, Salicylates.
- physiologie : Annelida.
- Animaux, Longévité, Oxydoréduction, Spectroscopie de résonance de spin électronique, Stress oxydatif.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Organometallic Compounds, Salicylates.
- physiology : Annelida.
- Animals, Electron Spin Resonance Spectroscopy, Longevity, Oxidation-Reduction, Oxidative Stress.
Abstract
Despite more than 50 years of investigations into the free radical theory, the direct role of oxidative stress (OS) in aging and age-related diseases remains unproven. Little progress in identifying antioxidant drugs promoting longevity has been made, likely due to selectivity toward one or few radical species, variable efficacy in vivo, inherent pro-oxidant behavior of such drugs, or lack of synergism with metabolic redox homeostasis. Silencing the wide range of reactive free radicals has a great impact on OS-linked outcomes and age-related disorders. Here we show that an innovative, redox-active, multi-radical-scavenger catalytic drug delays the age-associated decline in physiological processes and markedly prolongs the mean lifespan of the adult freshwater annelids Aeolosoma viride by 170%. This unprecedented extension is associated with a decreased OS status. Consistently, treatment of annelids increases their natural resistance to oxygen-derived damage without affecting mitochondrial respiration or reproductive activity. Conversely, the superoxide dismutase (SOD)-mimetic EUK 134 that we selected as a positive control led to an increase in lifespan of ~50%, the same increase previously observed in nematodes. Our results show that reduction of the global network of OS has a profound impact on aging, prompting the development of a possible redox-based therapeutic intervention to counteract the progression of aging.
DOI: 10.1093/gerona/glu160
PubMed: 25190068
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000176
- to stream PubMed, to step Curation: 000176
- to stream PubMed, to step Checkpoint: 000176
- to stream Ncbi, to step Merge: 003369
- to stream Ncbi, to step Curation: 003369
- to stream Ncbi, to step Checkpoint: 003369
- to stream Main, to step Merge: 000342
- to stream Main, to step Curation: 000342
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Redox-Based Flagging of the Global Network of Oxidative Stress Greatly Promotes Longevity.</title>
<author><name sortKey="Canistro, Donatella" sort="Canistro, Donatella" uniqKey="Canistro D" first="Donatella" last="Canistro">Donatella Canistro</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy and Biotechnology and donatella.canistro@unibo.it.</nlm:affiliation>
<country wicri:rule="url">Italie</country>
</affiliation>
</author>
<author><name sortKey="Boccia, Caterina" sort="Boccia, Caterina" uniqKey="Boccia C" first="Caterina" last="Boccia">Caterina Boccia</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Falconi, Rosanna" sort="Falconi, Rosanna" uniqKey="Falconi R" first="Rosanna" last="Falconi">Rosanna Falconi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bonamassa, Barbara" sort="Bonamassa, Barbara" uniqKey="Bonamassa B" first="Barbara" last="Bonamassa">Barbara Bonamassa</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmaceutical Sciences, University of Pittsburgh, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Pharmaceutical Sciences, University of Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Valgimigli, Luca" sort="Valgimigli, Luca" uniqKey="Valgimigli L" first="Luca" last="Valgimigli">Luca Valgimigli</name>
<affiliation><nlm:affiliation>Department of Chemistry "G. Ciamician" and.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Chemistry "G. Ciamician" and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vivarelli, Fabio" sort="Vivarelli, Fabio" uniqKey="Vivarelli F" first="Fabio" last="Vivarelli">Fabio Vivarelli</name>
<affiliation><nlm:affiliation>Department of Pharmacy and Biotechnology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Pharmacy and Biotechnology and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Soleti, Antonio" sort="Soleti, Antonio" uniqKey="Soleti A" first="Antonio" last="Soleti">Antonio Soleti</name>
<affiliation><nlm:affiliation>Department of Pharmacy and Biotechnology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Pharmacy and Biotechnology and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Genova, Maria Luisa" sort="Genova, Maria Luisa" uniqKey="Genova M" first="Maria Luisa" last="Genova">Maria Luisa Genova</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lenaz, Giorgio" sort="Lenaz, Giorgio" uniqKey="Lenaz G" first="Giorgio" last="Lenaz">Giorgio Lenaz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sapone, Andrea" sort="Sapone, Andrea" uniqKey="Sapone A" first="Andrea" last="Sapone">Andrea Sapone</name>
<affiliation><nlm:affiliation>Department of Pharmacy and Biotechnology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Pharmacy and Biotechnology and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zaccanti, Francesco" sort="Zaccanti, Francesco" uniqKey="Zaccanti F" first="Francesco" last="Zaccanti">Francesco Zaccanti</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abdel Rahman, Sherif Z" sort="Abdel Rahman, Sherif Z" uniqKey="Abdel Rahman S" first="Sherif Z" last="Abdel-Rahman">Sherif Z. Abdel-Rahman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Paolini, Moreno" sort="Paolini, Moreno" uniqKey="Paolini M" first="Moreno" last="Paolini">Moreno Paolini</name>
<affiliation><nlm:affiliation>Department of Pharmacy and Biotechnology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Pharmacy and Biotechnology and.</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:25190068</idno>
<idno type="pmid">25190068</idno>
<idno type="doi">10.1093/gerona/glu160</idno>
<idno type="wicri:Area/PubMed/Corpus">000176</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000176</idno>
<idno type="wicri:Area/PubMed/Curation">000176</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000176</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000176</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000176</idno>
<idno type="wicri:Area/Ncbi/Merge">003369</idno>
<idno type="wicri:Area/Ncbi/Curation">003369</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003369</idno>
<idno type="wicri:Area/Main/Merge">000342</idno>
<idno type="wicri:Area/Main/Curation">000342</idno>
<idno type="wicri:Area/Main/Exploration">000342</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Redox-Based Flagging of the Global Network of Oxidative Stress Greatly Promotes Longevity.</title>
<author><name sortKey="Canistro, Donatella" sort="Canistro, Donatella" uniqKey="Canistro D" first="Donatella" last="Canistro">Donatella Canistro</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy and Biotechnology and donatella.canistro@unibo.it.</nlm:affiliation>
<country wicri:rule="url">Italie</country>
</affiliation>
</author>
<author><name sortKey="Boccia, Caterina" sort="Boccia, Caterina" uniqKey="Boccia C" first="Caterina" last="Boccia">Caterina Boccia</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Falconi, Rosanna" sort="Falconi, Rosanna" uniqKey="Falconi R" first="Rosanna" last="Falconi">Rosanna Falconi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bonamassa, Barbara" sort="Bonamassa, Barbara" uniqKey="Bonamassa B" first="Barbara" last="Bonamassa">Barbara Bonamassa</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmaceutical Sciences, University of Pittsburgh, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Pharmaceutical Sciences, University of Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Valgimigli, Luca" sort="Valgimigli, Luca" uniqKey="Valgimigli L" first="Luca" last="Valgimigli">Luca Valgimigli</name>
<affiliation><nlm:affiliation>Department of Chemistry "G. Ciamician" and.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Chemistry "G. Ciamician" and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vivarelli, Fabio" sort="Vivarelli, Fabio" uniqKey="Vivarelli F" first="Fabio" last="Vivarelli">Fabio Vivarelli</name>
<affiliation><nlm:affiliation>Department of Pharmacy and Biotechnology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Pharmacy and Biotechnology and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Soleti, Antonio" sort="Soleti, Antonio" uniqKey="Soleti A" first="Antonio" last="Soleti">Antonio Soleti</name>
<affiliation><nlm:affiliation>Department of Pharmacy and Biotechnology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Pharmacy and Biotechnology and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Genova, Maria Luisa" sort="Genova, Maria Luisa" uniqKey="Genova M" first="Maria Luisa" last="Genova">Maria Luisa Genova</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lenaz, Giorgio" sort="Lenaz, Giorgio" uniqKey="Lenaz G" first="Giorgio" last="Lenaz">Giorgio Lenaz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sapone, Andrea" sort="Sapone, Andrea" uniqKey="Sapone A" first="Andrea" last="Sapone">Andrea Sapone</name>
<affiliation><nlm:affiliation>Department of Pharmacy and Biotechnology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Pharmacy and Biotechnology and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zaccanti, Francesco" sort="Zaccanti, Francesco" uniqKey="Zaccanti F" first="Francesco" last="Zaccanti">Francesco Zaccanti</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abdel Rahman, Sherif Z" sort="Abdel Rahman, Sherif Z" uniqKey="Abdel Rahman S" first="Sherif Z" last="Abdel-Rahman">Sherif Z. Abdel-Rahman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Paolini, Moreno" sort="Paolini, Moreno" uniqKey="Paolini M" first="Moreno" last="Paolini">Moreno Paolini</name>
<affiliation><nlm:affiliation>Department of Pharmacy and Biotechnology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Pharmacy and Biotechnology and.</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">The journals of gerontology. Series A, Biological sciences and medical sciences</title>
<idno type="eISSN">1758-535X</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Annelida (physiology)</term>
<term>Electron Spin Resonance Spectroscopy</term>
<term>Longevity</term>
<term>Organometallic Compounds (pharmacology)</term>
<term>Oxidation-Reduction</term>
<term>Oxidative Stress</term>
<term>Salicylates (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Annelida (physiologie)</term>
<term>Composés organométalliques (pharmacologie)</term>
<term>Longévité</term>
<term>Oxydoréduction</term>
<term>Salicylates (pharmacologie)</term>
<term>Spectroscopie de résonance de spin électronique</term>
<term>Stress oxydatif</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Organometallic Compounds</term>
<term>Salicylates</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Composés organométalliques</term>
<term>Salicylates</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Annelida</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Annelida</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Electron Spin Resonance Spectroscopy</term>
<term>Longevity</term>
<term>Oxidation-Reduction</term>
<term>Oxidative Stress</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Longévité</term>
<term>Oxydoréduction</term>
<term>Spectroscopie de résonance de spin électronique</term>
<term>Stress oxydatif</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Despite more than 50 years of investigations into the free radical theory, the direct role of oxidative stress (OS) in aging and age-related diseases remains unproven. Little progress in identifying antioxidant drugs promoting longevity has been made, likely due to selectivity toward one or few radical species, variable efficacy in vivo, inherent pro-oxidant behavior of such drugs, or lack of synergism with metabolic redox homeostasis. Silencing the wide range of reactive free radicals has a great impact on OS-linked outcomes and age-related disorders. Here we show that an innovative, redox-active, multi-radical-scavenger catalytic drug delays the age-associated decline in physiological processes and markedly prolongs the mean lifespan of the adult freshwater annelids Aeolosoma viride by 170%. This unprecedented extension is associated with a decreased OS status. Consistently, treatment of annelids increases their natural resistance to oxygen-derived damage without affecting mitochondrial respiration or reproductive activity. Conversely, the superoxide dismutase (SOD)-mimetic EUK 134 that we selected as a positive control led to an increase in lifespan of ~50%, the same increase previously observed in nematodes. Our results show that reduction of the global network of OS has a profound impact on aging, prompting the development of a possible redox-based therapeutic intervention to counteract the progression of aging.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
<li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
<li>Texas</li>
</region>
</list>
<tree><noCountry><name sortKey="Paolini, Moreno" sort="Paolini, Moreno" uniqKey="Paolini M" first="Moreno" last="Paolini">Moreno Paolini</name>
<name sortKey="Sapone, Andrea" sort="Sapone, Andrea" uniqKey="Sapone A" first="Andrea" last="Sapone">Andrea Sapone</name>
<name sortKey="Soleti, Antonio" sort="Soleti, Antonio" uniqKey="Soleti A" first="Antonio" last="Soleti">Antonio Soleti</name>
<name sortKey="Valgimigli, Luca" sort="Valgimigli, Luca" uniqKey="Valgimigli L" first="Luca" last="Valgimigli">Luca Valgimigli</name>
<name sortKey="Vivarelli, Fabio" sort="Vivarelli, Fabio" uniqKey="Vivarelli F" first="Fabio" last="Vivarelli">Fabio Vivarelli</name>
</noCountry>
<country name="Italie"><noRegion><name sortKey="Canistro, Donatella" sort="Canistro, Donatella" uniqKey="Canistro D" first="Donatella" last="Canistro">Donatella Canistro</name>
</noRegion>
<name sortKey="Boccia, Caterina" sort="Boccia, Caterina" uniqKey="Boccia C" first="Caterina" last="Boccia">Caterina Boccia</name>
<name sortKey="Falconi, Rosanna" sort="Falconi, Rosanna" uniqKey="Falconi R" first="Rosanna" last="Falconi">Rosanna Falconi</name>
<name sortKey="Genova, Maria Luisa" sort="Genova, Maria Luisa" uniqKey="Genova M" first="Maria Luisa" last="Genova">Maria Luisa Genova</name>
<name sortKey="Lenaz, Giorgio" sort="Lenaz, Giorgio" uniqKey="Lenaz G" first="Giorgio" last="Lenaz">Giorgio Lenaz</name>
<name sortKey="Zaccanti, Francesco" sort="Zaccanti, Francesco" uniqKey="Zaccanti F" first="Francesco" last="Zaccanti">Francesco Zaccanti</name>
</country>
<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Bonamassa, Barbara" sort="Bonamassa, Barbara" uniqKey="Bonamassa B" first="Barbara" last="Bonamassa">Barbara Bonamassa</name>
</region>
<name sortKey="Abdel Rahman, Sherif Z" sort="Abdel Rahman, Sherif Z" uniqKey="Abdel Rahman S" first="Sherif Z" last="Abdel-Rahman">Sherif Z. Abdel-Rahman</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000342 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000342 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Amérique |area= PittsburghV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:25190068 |texte= Redox-Based Flagging of the Global Network of Oxidative Stress Greatly Promotes Longevity. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25190068" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a PittsburghV1
This area was generated with Dilib version V0.6.38. |